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Paired box 6 (PAX6) regulates glucose metabolism via proinsulin processing mediated by prohormone convertase 1/3 (PC1/3)
Aims/hypothesis Human patients with aniridia caused by heterozygous PAX6mutations display abnormal glucose metabolism, but the underlying molecular mech...
文献获取Synthesis, characterization, interaction with DNA and cytotoxicity in vitro of novel Pyridines complexes with Zn(II)
Four novel Zn(II) complexes [Zn(L1)(bipy)(H2O)2]·4H2O(1), [Zn(L1)(phe- n)(H2O)2]·4H2O(2), [Zn(L2)(bipy)(H2O)2]·4H2O(3) and [Zn(L2)(phen)(H2O)2]·4H2O...
High-throughput identification of novel conotoxins from the Chinese tubular cone snail (Conus betulinus) by multi-transcriptome sequ...
The venom of predatory marine cone snails mainly contains a diverse array of unique bioactive peptides commonly referred to as conopeptides or conotoxin...
Research Advance of Facial Expression Recognition
Facial expression recognition(FER)is an active research topic in the fields of computer vision,machine learning and artificial intelligence,and has beco...
Bis(6-methyl-4-hydroxy-3-quinolinecarboxylate) Mono(oxo) Monohydroxyvanadium(Ⅴ)
The central V atom in bis[6-methyl-4-hydroxy-3-quinolinecarboxylate] mono(oxo)mono-hydroxy-vanadium(V) (1), synthesized by the hydrothermal treatment of...
Safety, tolerability, pharmacokinetics, and pharmacodynamics of TG103 injection in participants who are overweight or obese: a rando...
TG103, a glucagon-like peptide-1 analog, is being investigated as an option for weight management. We aimed to determine the safety, tolerability, pharm...
ABO and Rhesus blood groups and multiple health outcomes: an umbrella review of systematic reviews with meta-analyses of observation...
Numerous studies have been conducted to investigate the relationship between ABO and Rhesus (Rh) blood groups and various health outcomes. However, a co...
MicroRNA-122–Mediated Liver Detargeting Enhances the Tissue Specificity of Cardiac Genome Editing
Fei GaoDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, China (F.G.).Liang ChenState Key Laboratory of Cardiovascular Dise...
Robust ring insoluble naphthoquinone derivative cathode with high loading and long cycle life for aqueous zinc organic batteries
Organic materials for aqueous zinc ion batteries have been attracted the attention of researchers because of their high safety, environmental friendline...
Prohibitin 1 inhibits cell proliferation and induces apoptosis via the p53-mediated mitochondrial pathway in vitro
BACKGROUND Prohibitin 1(PHB1)has been identified as an antiproliferative protein that is highly conserved and ubiquitously expressed,and it participates...
